We have not examined 4E-BP3 because it is not thought to have a role in breast (Poulin et al, 1998), or phosphorylated forms of eIF4E, as their influences on the activity and in cancer remain uncertain (Scheper and Proud, 2002; Salehi and Mashayekhi, 2006; Buxade et al, 2008). Here, EIF4E is linked to cancer.