[24-28] It has also been reported that strong cytoplasmic staining in mammary carcinomas is associated with negative prognostic factors, such as low differentiation, p53, Ki-67 labeling etc. We have learned that despite nucleic expression, p53 tumor suppressor protein is localized on cell cytoplasm, where it is regarded as a way of functional inactivation. This evidence concerns the gene TCHP and breast carcinoma.