PPARA and Hepatic steatosis: However, despite strongexpression in the liver, proof of an eventual role of PPARs in hepatic diseaseremains limited to the link between hepatic tumorigenesis and chronicadministration of PPARα activators in rodents [8], the development of extensive hepatic steatosis inresponse to fasting and delayed liver regeneration in PPARα knock-out mice [9, 10], impaired expression of PPARα in a murine model ofalcoholic liver diseases [11], andimpaired liver expression of PPARα influenced by the HCVcore protein during chronic hepatitis C virus infection [12].