CertainPAI-1 tumor thresholds predict both poor prognosis and reduced disease-freesurvival in patients with breast, lung, ovarian, and oral SCC [29, 38] with the expression amplitude frequently associatedwith the 4G polymorphism at the PE1 E box motif in the PAI-1 promoter [37]. The gene discussed is SERPINE1; the disease is neoplasm.