CFHR5 and age-related macular degeneration: In addition, a replication study on the NEI dbGAP single nucleotide polymorphisms (SNPs) derived from the genome-wide association study on the Age-Related Eye Disease Study (AREDS) patient cohort demonstrates that many variants located in tandem on 1q32, including several in CFH, CFHR2, CFHR4, and CFHR5, were significantly associated with AMD risk [14].