To date, five genes, transforming growth factor beta induced factor homeobox 1 (TGIF) [59], paired box 6 (PAX6) [60], collagen, type 1, alpha 1 (COL1A1) [61], hepatocyte growth factor (HGF) [62], and uromodulin-like 1 (UMODL1) [27], have been positively associated with high grade myopia and collagen, type 2, alpha 1 (COL2A1) [63] with common myopia. The gene discussed is COL1A1; the disease is myopia.