The implication of NEDD4L in Liddle syndrome, genetic linkage of NEDD4L to a blood pressure phenotype, and evidence that ties the G/A variant to blood pressure variation and salt sensitivity, supported the hypotheses that NEDD4L participates in blood pressure regulation and that genetic variation in NEDD4L such as the G/A variant could contribute to individual differences to susceptibility to essential hypertension. Here, NEDD4L is linked to essential hypertension.