TLR2 and infection: In contrast, TLR4−/−, TLR2−/−, and WT mice—all of which can detect C. pneumoniae and can signal normally via MyD88, readily recovered from the infection and cleared bacteria normally, indicating that MyD88 is essential to an effective defense, but that TLR2 and TLR4 can both detect the pathogen and are therefore redundant [18],[19].