SLC2A4 and obesity due to melanocortin 4 receptor deficiency: Fourth, The Gly482Serpolymorphism is located in a highly conserved domain that was shown to interactwith and coactivate the muscle enhancer factor 2C that activates the GLUT4 gene[40].Importantly, the Ser482 allele was consistently observed to be associated with insulin resistance, T2DMor obesity.