COL18A1 and acute respiratory distress syndrome: There were significant linear associations between plasma endostatin at the onset of ALI and the global severity of illness markers APACHE II (r = 0.37, P = 0.038) and SAPS II (r = 0.44, P = 0.007) but not with lung injury score (r = -0.3, P = 0.9) (data not shown).