ALI patients had greater endostatin levels in BALF on both day 0 (median ALI 2.6 ng/ml, IQR = 0.24 to 0.64, P = 0.001) and day 4 (median ALI 1.36 ng/ml, IQR = 0.72 to 2.63, P = 0.01) than healthy individuals (0.08 ng/ml). The gene discussed is COL18A1; the disease is acute respiratory distress syndrome.