However, it should be mentioned that in two studies using vaccination with a DNA vaccine encoding CFP10, or a mix of several TB proteins, the vaccine induced CD8 T cells were shown to induce protection, demonstrating that in some instances CD8 T cells do provide protection against acute M.tb infection in a manner that is not strictly dependent upon simultaneous induction of CD4 T cells [5], [41]. Here, CD4 is linked to tuberculosis.