CCR5 and diabetic kidney disease: In summary, our study provides evidence of the individual risk associated with the inflammatory gene variants and also emphasizes on the combinatorial effect of alleles of the CCL2 (I allele of I/D polymorphism), CCR5 (D allele of I/D polymorphism) and MMP9 (279Gln allele of Arg279Gln) genes for diabetic nephropathy, considering the epistatic effects of individual genes, while investigating susceptibility genes in complex diseases like DN among Asian Indians.