For example, a promoter polymorphism (-2518A/G) in the CCL2 gene was found to be associated with progressive kidney failure in Koreans with type 2 diabetes [11] and TGFB1 T869C gene polymorphism showed association with nephropathy in type 2 diabetic Chinese patients [12]. This evidence concerns the gene TGFB1 and type 2 diabetes mellitus.