In the present study, we investigated combinatorial polymorphisms among five inflammatory genes (TGFB1: T869C (Leu10Pro) and Tyr81His; CCL2: A-2518G and Insertion/Deletion (I/D); CCR5: Insertion/Deletion (I/D) and G59029A; IL8: T-251A; MMP9: Arg279Gln (G>A)) for association with the risk of susceptibility to diabetic nephropathy. This evidence concerns the gene CXCL8 and diabetic kidney disease.