In summary, our study provides evidence of the individual risk associated with the inflammatory gene variants and also emphasizes on the combinatorial effect of alleles of the CCL2 (I allele of I/D polymorphism), CCR5 (D allele of I/D polymorphism) and MMP9 (279Gln allele of Arg279Gln) genes for diabetic nephropathy, considering the epistatic effects of individual genes, while investigating susceptibility genes in complex diseases like DN among Asian Indians. The gene discussed is MMP9; the disease is diabetic kidney disease.