When patients' data were analyzed according to the presence (n = 28) and absence (n = 64) of LVI by either method, H&E or D2–40, no correlation was found according to patients' age, tumor size, histological type or grade, MVD counts (CD34), LVD (D2–40), VEGF-A, HER-2/neu and hormonal receptor status, or to SLN status. The gene discussed is VEGFA; the disease is neoplasm.