APP and Alzheimer disease: We have recently found that the canine is also a suitable AD model from the molecular point of view, because APP and most of the enzymatic machinery for its processing bear extensive homology between dogs and humans (GenBank accessions AY926579 for APP770, AY926580 for APP751, AY926581 for APP714, AY926582 for APP695, AY926587 for ApoE, AY926590 for presenilin-1, AY926591 for presenilin-2, AY926592 for BACE, AY926593 for ADAM-10, AY926594 for ADAM-17 and AY926595 for pleckstrin).