CDK6 and hematologic disorder: Figure 2B displays selected aberrations. MYCN and CDK6 amplifications were identified. MYCN region amplification appears only in groups 1–3. Amplification of the CDK6 region appears mostly in groups 1 and 2. NPM1 (Nucleophosmin, B23) was deleted in few samples. NPM1 has been recognized as a partner gene for various chromosomal translocations in hematological malignancies. NPM1 was associated with centrosome duplication and the regulation of p53, and might have a role as a tumor suppressor.47