To better understand the pathogenesis of diffuse large cell B lymphomas (DLBCLs) which often exhibit deregulated BCL6 expression, ChIP-on-chip studies have focused on determining direct BCL-6 target genes, and demonstrate that these targets involved in BCL-6 regulated pathways were indeed deregulated in some DLBCLs (Polo et al. 2007). Here, BCL6 is linked to diffuse large B-cell lymphoma.