HIF-1α expression was positively correlated with those of CXCR4 and CXCR7 among tumour specimens (HIF-1α-CXCR4, Spearman's r=0.55, P<0.0001; HIF-1α-CXCR7, Spearman's r=0.29, P=0.013). The gene discussed is ACKR3; the disease is neoplasm.