CXCR4 and neoplasm: Although the rate of global recurrence was similar between CXCR4high and CXCR4low tumours, occurrence of liver metastasis, was significantly more frequent in CXCR4high than CXCR4low; this can explain why CXCR4 expression failed to strongly predict DFS whereas it appears to be a very good predictor for OS.