MAPK8 and colonic neoplasm: Some reports suggest that JNK is not activated by TRAIL in colon cancers regardless of their sensitivity to TRAIL (Zhang et al, 2004), whereas others suggest that JNK activation augments TRAIL-induced apoptosis in a number of other tumours (Herr et al, 1999; Li et al, 2006; Mikami et al, 2006).