Some reports suggest that JNK is not activated by TRAIL in colon cancers regardless of their sensitivity to TRAIL (Zhang et al, 2004), whereas others suggest that JNK activation augments TRAIL-induced apoptosis in a number of other tumours (Herr et al, 1999; Li et al, 2006; Mikami et al, 2006). This evidence concerns the gene TNFSF10 and colonic neoplasm.