FHIT and exocrine pancreatic carcinoma: Similarly, for the FHIT gene and the other fragile site-related genes, deletion at the WWOX (FRA16D) locus and resultant loss of WWOX expression have been shown to promote cell transformation and immortalisation in various human malignancies (Paige et al, 2001; Driouch et al, 2002; Kuroki et al, 2002); however, the incidence of LOH was infrequent in pancreatic carcinoma (Kuroki et al, 2004; Nakayama et al, 2008) and we could not detect LOH in this series of IPMNs (data not shown).