WWOX and pancreatic intraductal papillary-mucinous neoplasm: Restoration of the WWOX gene in pancreatic carcinoma PANC-1 (WWOX-negative) cells effectively suppressed cell growth and induced caspase-dependent apoptosis; we therefore estimated the possible relationship between low levels of WWOX expression and higher growth rate or infrequent incidence of apoptosis in IPMN.