Recent studies have shown that the WW1 domain of the WWOX protein has an essential function in its tumour suppressor function by regulating the subcellular localisation of p73 (Aqeilan et al, 2004a) and AP-2γ (Aqeilan et al, 2004b), both of which contain the proline-rich ligand ‘PPXY’ motif. Here, WWOX is linked to neoplasm.