Recent study on the combination of six different biomarkers (CRP, PCT, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor and soluble triggering receptor expressed on myeloid cells-1) for the detection of bacterial versus non-bacterial febrile illness in patients with systemic inflammatory response syndrome reported an AUC of 0.88 [23]. This evidence concerns the gene CRP and systemic inflammatory response syndrome.