While the original objective of our randomized trial had been to examine effects of two daily soy servings on steroid hormones and mammographic densities [6,18], the aim of the current study was to examine the effects of soy foods on serum markers of obesity and systemic inflammation, interleukin (IL)-6, IL-2, CRP, leptin, and adiponectin, in premenopausal healthy women. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.