RYR2 and catecholaminergic polymorphic ventricular tachycardia: Within the current decade, discovery of numerous RyR2 gene mutations which underlie the arrhythmogenesis that leads to sudden cardiac death (SCD) in catecholaminergic polymorphic ventricular tachycardia (CPVT), have added a new focus to the role of RyR2 dysfunction in cardiac disease (Priori et al., 2001; George et al., 2007).