The R176Q mutation showed no histological evidence typical of human ARVD2 changes in the right ventricle but there was evidence of cardiomyopathy, in 1 year old mice, in the form of decreased end-diastolic volume of the right and left ventricles and higher end-diastolic pressure in the left ventricle (Kannankeril et al., 2006). The gene discussed is RYR2; the disease is cardiomyopathy.