RYR2 and hydrops fetalis: Three-fold over expression of CaMKII in a transgenic mouse model resulted in HF at three months and the isolated cardiomyocytes showed a 50% reduction in SR store Ca2+, with reduced SERCA and increased NCX expression together with an increase in spontaneous Ca2+ sparks suggesting diastolic leak from RyR2 (Maier et al., 2003).