CASP4 and Alzheimer disease: As inflammatory processes may change with age, we included age of death as a covariate, and observed that the increase of caspases-4 expression in AD subjects remained significant (F1, 87 = 4.375, p = 0.039) [as did the decreases in FE65 (p = 0.002), Teashirt1 (p = 0.013), Teashirt2 (p = 0.001), and Teashirt3 (p<0.0005)].