To examine whether IP-10 deletion also affected systemic IFN-γ responses to malaria, serum IFN-γ levels were determined in wild-type and IP-10−/− mice at day 5 p.i. Interestingly, serum IFN-γ content was significantly lower in malaria-infected IP-10−/− mice compared to wild-type control animals (Figure S1). This evidence concerns the gene CXCL10 and malaria.