When plotted against FOXP3 mRNA levels measured on day 0, a linear by linear hyperbolic fit revealed that higher levels of FOXP3 mRNA on day 0 were highly significantly (p = 0.009) associated with lower malaria-specific IFN-γ memory responses on Day 28, suggesting that Tregs induced during the acute infection may limit the magnitude of subsequent Th1 responses (Figure 7B). This evidence concerns the gene IFNG and malaria.