CD4 and malaria: Intriguingly, the proportion of these cells within the total CD4+ T cell population was significantly higher in children with uncomplicated malaria than in children with severe malaria suggesting that in human P. falciparum infection, as in murine T.gondii infections [50], IL-10 producing Th1 cells, activated by a strong inflammatory stimulus, may act as anti-parasitic effector cells with a “built in” control mechanism to prevent the onset of immune pathology.