When plotted against FOXP3 mRNA levels measured on day 0, a linear by linear hyperbolic fit revealed that higher levels of FOXP3 mRNA on day 0 were highly significantly (p = 0.009) associated with lower malaria-specific IFN-γ memory responses on Day 28, suggesting that Tregs induced during the acute infection may limit the magnitude of subsequent Th1 responses (Figure 7B). The gene discussed is FOXP3; the disease is malaria.