We have previously describeda “cue-signal-response” (CSR) compendium of protein signals andphenotypic responses in HT-29 human colon carcinoma cells treated with combinationsof tumor necrosis factor-α (TNF), epidermal growth factor (EGF), and insulin[43].The compendium includes ten measurements of protein modification states(phosphorylation and cleavage) and kinase activities for four proteins downstream ofTNF, EGF and insulin receptors collected over a 24 hr time period in biologicaltriplicate. The gene discussed is EGF; the disease is colon carcinoma.