In the present study, we found that ketamineinhibited ERK1/2 but not JNK1/2 or p38 MAPK phosphorylation in LPS-stimulated microglia.Zhang et al. [26] havereported that ketamine could abolish hyperglycemia-activated ERK1/2phosphorylation through inhibition of the N-methyl D-aspartate-mediated calciuminflux, which subsequently reducesthe hyperglycemia-exaggerated damage [26]. This evidence concerns the gene MAPK8 and Hyperglycemia.