CDKN2A and type 2 diabetes mellitus: The most replicated SNPs associated with strongest effect sizes for atherosclerotic disease and T2DM are >100 kb centromeric to the INK4/ARF locus (Fig. 1), which encodes three cell cycle inhibitors (p15INK4b, p16INK4a, ARF, reviewed in [12]) and a recently discovered putative non-coding RNA designated ANRIL[13].