Although, ex vivo tests based on cellular immune response (IGRAs) performed in HIV-infected individuals with advanced immunodeficiency (with CD4+ lower than 100 cells / μL) have been shown to be associated with a high proportion of indeterminate results, the anti-PGL-Tb1 antibodies levels have been demonstrated to be independent of the CD4+ cell counts [63]. The gene discussed is CD4; the disease is immune system disorder.