Nevertheless, the heterogeneity of human individuals observed with several factors (33%; n = 8) including ID3, IRF9, IRF7, TCF7L2, HDAC7/9, OCT2, PCAF and MEF2B raises a possibility that functional capacities of individual macrophages might determine differential susceptibility to and severity of various immune diseases. The gene discussed is IRF7; the disease is immune system disorder.