We substantiated the concept of a direct functional role for the CREB and AhR transcription factors by the following novel findings: 1) both proteins are physically associated with the −219/+7 FSCN1 promoter region in fascin-positive SW480 human colon carcinoma cells; 2), as confirmed by qRT-PCR, these associations are not detectable in fascin-negative SW1222 human colon carcinoma cells. Here, FSCN1 is linked to colon carcinoma.