The fact that 99% of cervical cancers contain HPV DNA [2] as is the case for most of the cervical cancer cell lines in which we demonstrated homozygous LKB1 deletions (e.g. HeLa harbors integrated HPV-18 sequences) [30] suggest that LKB1 and HPV cooperate in some manner. This evidence concerns the gene STK11 and cervical carcinoma.