Then, BRCA1 5382insC mutation testing was performed for her affected mother (II.6, BC at age 66), her sisters (III.4, healthy; III.5, affected by BC at age 52, i.e. after the initial counseling in the year 2002; III.6, BC at age 35), and her healthy 31-years-old nephew whose mother (III.11) survived BC at age 35 but died from OC at 50. Here, BRCA1 is linked to breast cancer.