BRCA1 and BRCA2 mutations occur in approximately 0.2–1% healthy subjects, 5% non-selected breast cancer (BC) patients, 15% consecutive ovarian cancer (OC) cases, and 25% females with clinical features of hereditary breast-ovarian cancer (HBOC) syndrome [1-8]. The gene discussed is BRCA2; the disease is Hereditary breast and ovarian cancer syndrome.