These observations raise the possibility that VEGF-A/FLJ10540/PI3K/AKT might be in the same pathway, despite the fact that the gene expression patterns of AKT in our lung cancer microarray dataset did not exhibit any correlation with FLJ10540. This is not surprising, because the activation state of the PI3K signaling pathway is monitored by phosphorylated AKT. The gene discussed is PIK3CA; the disease is lung cancer.