PIK3CA and breast carcinoma: [14]–[17]. Further evidence of the importance of PI3K/AKT signaling in cancer comes from studies which have detected overexpression and hyperactivation of PI3K/AKT in a wide range of human tumors, including lung cancer, and this is often linked with poor prognosis [18]. Accumulating evidence from previous reports suggests a potential role of PI3K/AKT in migration and invasion of various cell types, including lung cancer [19], liver cancer [20], breast cancer [21], and pancreatic cancer [22].