As described in the methods section, immunoglobulin endpoints were calculated for the different VLP antigens using asymptotic covariance matrix V method by regression analysis with four variables: antigen class, immunoglobulin class (IgM, IgG), primary or secondary infection status, and the resident country of infected patients (Puerto Rico or Taiwan); and a general least squares (GLS) approach was applied to determine endpoints. This evidence concerns the gene CD40LG and infection.