Analogous, TDP-43 immunohistochemistry now also enables the investigation of the co-occurrence of FTLD-U type TDP-43 pathology in the setting of other neurodegenerative disorders and indeed some degree of TDP-43 pathology has now been reported in a variety of other neurodegenerative diseases besides FTLD and ALS. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.