Another common alteration in diffuse astrocytomas is overexpression of the platelet-derived growth factor receptor alpha (PDGFRA) and its ligand PDGFalpha [15]; PDGFRA amplification, however, is restricted to a small subset of high-grade gliomas, in particular glioblastomas [16] (Figure 1). Here, PDGFRA is linked to glioblastoma.