Lee et al. [107] demonstrated that human HCT-8 colon cancer cells with decreased mtDNA content exhibited higher tolerance to doxorubicin or vincristine, and that mtDNA depletion induced an increase in the expression level of mRNA of multidrug resistance 1 (MDR1) gene and its translated P-glycoprotein [107]. The gene discussed is ABCB1; the disease is malignant colon neoplasm.