Earlier attempts to model ALS yielded confusing results as expression of hSOD1 transgene and human mutated Gly41-to-Ser SOD in motorneurons by D42-GAL4 led to increased longevity and could rescue the lifespan of a dSod null mutant with shortened lifespan [105,106]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.