In flies expressing wildtype fly LRRK and the Arg1069Cys mutation corresponding to pathogenic Arg1441Cys mutation in LRRK2 associated with PD [63] under control of various GAL4 driver lines inducing whole body, muscle, eye and dopaminergic neuron specific expression did not show defects, but LRRK loss-of-function mutants showed decreased locomotor activity and reduction of dopaminergic neurons [64]. Here, LRRK2 is linked to Parkinson disease.