MAPT and neurodegenerative disease: Neurofibrillary tangles (NFT), neuritic plaques and neuropil threads composed of hyperphosphorylated tau forming intraneuronal inclusions are characteristic of AD, but tau inclusions are also associated with other neurodegenerative diseases such as Pick’s disease, corticobasal degeneration, argyrophilic grain disease, progressive supranuclear palsy and fronto-temporal lobar degeneration (FTLD) [41] characterized by diverse clinico-pathological phenotypes from aphasia to dementia syndromes [42].