The patogenicity of the Vibrio cholerae strains belonging to serogroup O1 and O139 is due to the production of virulence factors such as cholera toxin (CT) and the toxin-coregulated pilus (TCP); CT is essential for full-blown cholera whereas TCP is crucial for the adherence of bacteria to the intestinal epithelium [2], [3]. The gene discussed is SPINK1; the disease is vibrio infectious disease.