Rather, based on our previous study showing that VEGFR2 inhibition inhibits de novo adipogenesis by restricting angiogenesis [21], and studies by others showing the importance of VEGF and VEGFR2 signaling in adipose tissue development [5], [29], [30], we hypothesized that inhibition of VEGFR2 in adipose tissue may have weight-reducing effects in diet-induced obesity. Here, VEGFA is linked to obesity due to melanocortin 4 receptor deficiency.