IGHG3 and vibrio infectious disease: Although we similarly hypothesized that helminth infected cholera patients may have Th2>Th1 polarized immune responses, with class switch recombination favoring intact responses of IgE and IgG4 antibodies and relatively diminished IgG1 and IgG3 responses [27], only IgG1 was significantly different between helminth infected and non-infected individuals.