DCC and colorectal carcinoma: More than 90% of the primary CRCs with loss of LOH of chromosome 18q show a deletion in the colorectal carcinoma (DCC) gene included in the region of allelic loss.[70, 81, 82] Several studies have linked chromosome 18q LOH in CRCs to a reduction in DCC expression at the RNA level[82, 83] and the protein level,[84–86] although some studies have failed to find evidence for reduced DCC transcript and/or protein levels in CRCs.[87] Therefore, the findings do little to establish whether DCC loss /inactivation is a critical factor in carcinogenesis or merely an epiphenomenon.