The most important point that determines the borderline between the adenoma and the adenocarcinoma is a mutation of the p53 gene.[70] The p53 gene is a typical tumor suppressor gene and its mutation has been detected in a variety of cancers, the mutation or LOH being present in about 75% of CRCs.[97] On the other hand, it is thought that this mutation is a conversion point from adenoma to adenocarcinoma because it is rarely detected in adenoma. Here, TP53 is linked to adenoma.