Gene expression was altered in the inflamed colon of mice that received a combination of AOM and DSS in comparison with that of untreated mice or mice treated with either AOM or DSS alone.[168] Significantly upregulated genes in the AOM/DSS group include Wif1, Plat, and Myc at week 5 and Plscr2 at week 10. Here, WIF1 is linked to infectious otitis media.