However, K-ras mutations are found in 9% of adenomas less than 1 cm in size.[65] In addition, due to the identification of the same point mutation in the same patient's adenoma and adenocarcinoma, it is thought that the mutation of the K-ras gene occurs during the early stage of carcinogenesis and is related in an increase of the size of the tumor. This evidence concerns the gene KRAS and adenocarcinoma.