GO-Y030, FLLL-11, and FLLL-12 at 2.5 and 5 μM induced cleaved PARP and cleaved caspase-3 in HCT116 colorectal cancer cells as evidenced by increased levels of cleaved PARP and cleaved caspase-3 while 10 and 20 μM of curcumin induced increased levels of cleaved PARP and caspase-3 (Figure 3A). The gene discussed is CASP3; the disease is colorectal cancer.