The patients with a homogeneous IIF-ANA staining pattern, and a concomitant chromosomal staining, had a tendency to show clinical signs compatible with systemic lupus erythematosus, SLE (with e.g. musculoskeletal disorders, skin disorders, anaemia, thrombocytopenia, polymyositis and fever). Here, BTG3 is linked to musculoskeletal system disorder.