TNF and neoplasm: Three dogs out of 14 (21%) were euthanized due to progressive disease and underwent rapid (warm) necropsy; pathologic evaluation of visceral organs (brain, heart, lung, liver, spleen, gastrointestinal tract, kidneys, and lymph nodes) did not detect any treatment related histologic abnormalities in these organs; data supporting the relative safety and tumor-targeting of RGD-A-TNF.