[1], [2], [3]. The first study of the COTC (COTC001) provides an example of this integration and a functional infrastructure that may deliver trial outcomes in a timely manner. Specifically, COTC001 assessed the safety, selective tumor-specific localization, and anti-tumor activity of RGD-A-TNF in dogs with measurable malignant cancers. This evidence concerns the gene TNF and neoplasm.