In a recent report, using a meta-analysis of pedigree data from 498 BRCA1 and BRCA2 mutation carriers identified through population-based studies of women with breast and ovarian cancer, the authors have shown, albeit not significantly, that cancer risk by age 50 years is lower for 185delAG than 5382insC BRCA1 mutation carriers.19, 33 Our data are consistent with this. This evidence concerns the gene BRCA2 and cancer.