BRCA1 and breast carcinoma: Figure 2 shows that median age of affliction with breast cancer was 55 years for 185delAG in exon 2 (hazard ratio (HR) 0.23, 95% CI 0.095 to 0.55, p = 0.001) and 47 years for the 4184delTCAA mutation in exon 11 (HR 0.49, 95% CI 0.225 to 1.08, p = 0.076) compared with 41 years for exon 13 duplication of the BRCA1 gene.