However, Unger et al reported a Belgian woman with this mutation who developed cancer at age 34 years.30 Moreover, Yap et al reported a woman diagnosed with bilateral breast cancer at ages 32 and 41 years and her sister, carrying the same exon 13 duplication mutation, was diagnosed with ovarian cancer at age 43 years.31 For the 185delAG BRCA1 mutation, although the frequency of the mutation was, as expected, among the highest, we report significantly lower cancer rates in carriers of this mutation. This evidence concerns the gene BRCA1 and cancer.