In contrast to VEGFR1 and VEGFR2, NRP-1 expression was down-regulated in early ARDS lung (P < .05, Bonferroni) versus normal lung with significant up-regulation in later ARDS (P < .001, Bonferroni) versus early ARDS (Fig. 5C). The gene discussed is FLT1; the disease is acute respiratory distress syndrome.