Growth factor related genes down-regulated in tumour samples are: BMP4, found to inhibit the tumorigenic potential of human brain tumor initiating cells[27]; MAP2K2, a regulator of G1/S transition [28] and LTBP4, reported to be down-regulated in human mammary adenocarcinoma [29];. The gene discussed is LTBP4; the disease is breast adenocarcinoma.