Similarly, in highdoses, MS-275 has shown such toxicityas nausea, vomiting, anorexia, fatigue, hypoalbuminemia, and hypocalcemia inclinical trials [45].The HDAC inhibitor romidepsin has additionally been associatedwith atrial fibrillation, tachycardia, and in one case a cardiac sudden death [46].Synergism would allow lower doses to be used. The gene discussed is HDAC9; the disease is Hypocalcemia.